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Regulation of Cullin-RING E3 ligase dynamics by Inositol hexakisphosphate [Biochemistry]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-03-24
Daniel C. Scott, Gary Kleiger

Perhaps in a decade or so, researchers may look back on current times and view it as an inflection point for the development of novel therapeutic modalities for the treatment of various human diseases. One particularly innovative approach involves targeting disease-modifying proteins for degradation by the proteasome, the large multisubunit...

中文翻译:

肌醇六磷酸磷酸酯对Cullin-RING E3连接酶动力学的调控[生物化学]

大概在十年左右的时间里,研究人员可能会回顾当前的时代,并将其视为开发用于治疗各种人类疾病的新型治疗方法的拐点。一种特别创新的方法涉及靶向疾病修饰蛋白,以被蛋白酶体,大型多亚基降解。
更新日期:2020-03-26
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