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Disruption of cellular proteostasis by H1N1 influenza A virus causes {alpha}-synuclein aggregation [Medical Sciences]
Proceedings of the National Academy of Sciences of the United States of America ( IF 11.1 ) Pub Date : 2020-03-24
Rita Marreiros, Andreas Muller–Schiffmann, Svenȷa V. Trossbach, Ingrid Prikulis, Sebastian Hansch, Stefanie Weidtkamp–Peters, Ana Raquel Moreira, Shriya Sahu, Irina Soloviev, Suganya Selvaraȷah, Vishwanath R. Lingappa, Carsten Korth

Neurodegenerative diseases feature specific misfolded or misassembled proteins associated with neurotoxicity. The precise mechanisms by which protein aggregates first arise in the majority of sporadic cases have remained unclear. Likely, a first critical mass of misfolded proteins starts a vicious cycle of a prion-like expansion. We hypothesize that viruses, having...

中文翻译:

H1N1甲型流感病毒破坏细胞蛋白稳定导致{α}-突触核蛋白聚集[医学]

神经退行性疾病的特征是与神经毒性有关的特定错误折叠或错误组装的蛋白质。大多数散发病例中首先出现蛋白质聚集的确切机制仍不清楚。可能,错误折叠的蛋白质的第一临界质量开始了a病毒样扩增的恶性循环。我们假设病毒具有...
更新日期:2020-03-26
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