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Disruption of cellular proteostasis by H1N1 influenza A virus causes {alpha}-synuclein aggregation [Medical Sciences]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.580 ) Pub Date : 2020-03-24
Rita Marreiros, Andreas Muller–Schiffmann, Svenȷa V. Trossbach, Ingrid Prikulis, Sebastian Hansch, Stefanie Weidtkamp–Peters, Ana Raquel Moreira, Shriya Sahu, Irina Soloviev, Suganya Selvaraȷah, Vishwanath R. Lingappa, Carsten Korth

Neurodegenerative diseases feature specific misfolded or misassembled proteins associated with neurotoxicity. The precise mechanisms by which protein aggregates first arise in the majority of sporadic cases have remained unclear. Likely, a first critical mass of misfolded proteins starts a vicious cycle of a prion-like expansion. We hypothesize that viruses, having...
更新日期:2020-03-26

 

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