In recent years, nano drug delivery system has been widely concerned because of its good therapeutic effect. However, the process from blood circulation to cancer cell release of nanodrugs will be eliminated by the human body's own defense trap, thus reducing the therapeutic effect. In recent years, a “3S” transition concept, including stability transition, surface transition and size transition, was proposed to overcome the barriers in delivery process. Hyaluronic (HA) acid has been widely used in delivery of anticancer drugs due to its excellent biocompatibility, biodegradability and specific targeting to cancer cells. In this paper, the strategies and methods of HA-based nanomaterials using “3S” theory are reviewed. The applications and effects of “3S” modified nanomaterials in various fields are also introduced.

近年来，纳米药物递送系统由于其良好的治疗效果而受到广泛关注。但是，从血液循环到癌细胞释放纳米药物的过程将被人体自身的防御陷阱所消除，从而降低了治疗效果。近年来，提出了“ 3S”过渡概念，包括稳定性过渡，表面过渡和尺寸过渡，以克服交付过程中的障碍。透明质酸（HA）由于其出色的生物相容性，生物降解性和对癌细胞的特异性靶向作用，已被广泛用于抗癌药物的递送。本文综述了基于“ 3S”理论的HA基纳米材料的策略和方法。还介绍了“ 3S”改性纳米材料在各个领域的应用和效果。