当前位置: X-MOL 学术Neurotoxicology › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.
NeuroToxicology ( IF 3.4 ) Pub Date : 2020-03-24 , DOI: 10.1016/j.neuro.2020.03.007
Emily N Dunn 1 , Liana M Matson 1 , Kari M Haines 1 , Kimberly A Whitten 2 , Robyn B Lee-Stubbs 3 , Kyle E Berger 1 , Hilary S McCarren 1 , Cherish E Ardinger 1 , Cecelia E Jackson Piercy 1 , Stephanie M Miller-Smith 1 , John H McDonough 1
Affiliation  

Multiple recent instances of nerve agent (NA) exposure in civilian populations have occurred, resulting in a variety of negative effects and lethality in both adult and pediatric populations. Seizures are a prominent effect of NAs that can result in neurological damage and contribute to their lethality. Current anticonvulsant treatments for NAs are approved for adults, but no approved pediatric treatments exist. Further, the vast majority of NA-related research in animals has been conducted in adult male subjects. There is a need for research that includes female and pediatric populations in testing. In this project, adult and pediatric male and female rats were challenged with sarin or VX and then treated with fosphenytoin, levetiracetam, or propofol. In this study, fosphenytoin and levetiracetam failed to terminate seizure activity when animals were treated 5 min after seizure onset. Propofol was effective, exhibiting high efficacy and potency for terminating seizure activity quickly in pediatric and adult animals, suggesting it may be an effective anticonvulsant for NA-induced seizures in pediatric populations.

中文翻译:

评估磷苯妥英钠,左乙拉西坦和丙泊酚作为治疗小儿和成年大鼠神经制剂引起的癫痫发作的方法。

最近在平民人群中发生了多次神经毒剂(NA)暴露的事件,导致成人和儿科人群均遭受各种负面影响和致死性。癫痫发作是NAs的重要作用,可导致神经系统损害并增加其致死性。目前,NAs的抗惊厥治疗已获准用于成人,但尚无批准的儿科治疗。此外,绝大多数与NA有关的动物研究都是在成年男性受试者中进行的。需要进行包括女性和儿童人群在内的研究。在该项目中,用沙林蛋白或VX攻击成年和小儿雄性和雌性大鼠,然后用磷苯妥英钠,左乙拉西坦或丙泊酚治疗。在这个研究中,当癫痫发作后5分钟对动物进行治疗时,磷苯妥英钠和左乙拉西坦未能终止癫痫发作活动。丙泊酚是有效的,在儿科和成年动物中表现出快速终止癫痫发作活动的高功效和潜能,表明它可能是NA引起的小儿人群癫痫发作的有效抗惊厥药。
更新日期:2020-03-24
down
wechat
bug