For tissue engineering (TE), triply periodic minimal surfaces (TPMSs) have received widespread application, as they produce smooth surfaces and pore interconnectivity, which can satisfy the biological/mechanical requirements and efficiently construct many complex bone scaffolds. To control the microstructure of the scaffold and mimic the anisotropy of native tissue, a design approach for heterogeneous porous scaffolds is proposed in this paper. It is carried out by discretizing the original model using the conformal refinement of an all-hexahedral mesh and mapping the TPMS units to the mesh elements with the help of a shape function. Another aim of this work is to assess the impact on the biologic/mechanical properties of the model, as it is discretized with different mesh patterns. It is found that the mesh pattern has a non-obvious effect on the surface curvature distribution that is a crucial factor to osteoblast proliferation in the TPMS scaffold. Nevertheless, the comparison presents that the mechanical properties of the refined scaffolds model exhibited anisotropy and improvements in elasticity, strengths, and especially energy absorption. With the help of conformal remeshing, the local density of architecture can be conveniently controlled and the elastic modulus of scaffold can be designed to the appropriate range in a specified area in order to mimic the actual cancellous bone.

对于组织工程（TE），三周期周期性最小表面（TPMS）已得到广泛的应用，因为它们产生光滑的表面和孔互连，可以满足生物学/机械要求并有效地构造许多复杂的骨支架。为了控制支架的微观结构并模拟天然组织的各向异性，提出了一种异质多孔支架的设计方法。它是通过使用全六面体网格的保形改进离散化原始模型，然后借助形状函数将TPMS单元映射到网格元素来实现的。这项工作的另一个目的是评估对模型的生物学/机械特性的影响，因为模型具有不同的网格图案。发现网状图案对表面曲率分布具有非显而易见的影响，这是TPMS支架中成骨细胞增殖的关键因素。然而，比较结果表明，改进的脚手架模型的机械性能表现出各向异性，并且在弹性，强度，尤其是能量吸收方面表现出改善。借助保形重塑，可以方便地控制建筑的局部密度，并可以在指定区域内将支架的弹性模量设计为合适的范围，以模仿实际的松质骨。比较结果表明，改进的脚手架模型的机械性能表现出各向异性，并且在弹性，强度，尤其是能量吸收方面有所改善。借助保形重塑，可以方便地控制建筑的局部密度，并可以在指定区域内将支架的弹性模量设计为合适的范围，以模仿实际的松质骨。比较结果表明，改进的脚手架模型的机械性能表现出各向异性，并且在弹性，强度，尤其是能量吸收方面有所改善。借助保形重塑，可以方便地控制建筑的局部密度，并且可以在特定区域内将支架的弹性模量设计为合适的范围，以模仿实际的松质骨。