Current platinum-based drugs used in chemotherapy, like cisplatin and its derivatives, are greatly limited due to side-effects and drug resistance. This has inspired the search for novel platinum-based drugs that deviate from the conventional mechanism of action seen with current chemotherapeutics. This review highlights recent advances in platinum(II) and platinum(IV)-based complexes that have been developed within the past six years. The platinum compounds explored within this review are those that display a more targeted approach by incorporating ligands that act on selected cellular targets within cancer cells. This includes mitochondria, overexpressed receptors or proteins and enzymes that contribute to cancer cell proliferation. These types of platinum compounds have shown significant improvements in anticancer activity and as such, this review highlights the importance of pursuing these new designed platinum drugs for cancer therapy, with the potential of undergoing clinical trials.

中文翻译：

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铂基化学治疗药物的最新进展显示出抑制作用和靶向作用机制。

由于副作用和耐药性，目前用于化疗的铂基药物（如顺铂及其衍生物）受到很大限制。这激发了人们寻求不同于当前化学疗法所见常规作用机理的新型铂基药物的机会。这篇综述重点介绍了过去六年来在铂（II）和铂（IV）基络合物方面的最新进展。本综述中探讨的铂化合物是那些通过掺入对癌细胞内选定细胞靶标起作用的配体而显示出更具针对性的方法的铂化合物。这包括线粒体，过表达的受体或有助于癌细胞增殖的蛋白质和酶。这些类型的铂化合物已显示出显着的抗癌活性改善，因此，