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In Vivo Characterization of Neurophysiological Diversity in the Lateral Supramammillary Nucleus during Hippocampal Sharp-wave Ripples of Adult Rats.
Neuroscience ( IF 3.3 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.neuroscience.2020.03.034
Ana F Vicente 1 , Andrea Slézia 1 , Antoine Ghestem 1 , Christophe Bernard 1 , Pascale P Quilichini 1
Affiliation  

The extent of the networks that control the genesis and modulation of hippocampal sharp-wave ripples (SPW-Rs), which are involved in memory consolidation, remains incompletely understood. Here, we performed a detailed in vivo analysis of single cell firing in the lateral supramammillary nucleus (lSuM) during theta and slow oscillations, including SPW-Rs, in anesthetized rats. We classified neurons as SPW-R-active and SPW-R-unchanged according to whether or not they increased their firing during SPW-Rs. We show that lSuM SPW-R-active neurons increase their firing prior to SPW-Rs peak power and prior to hippocampal excitatory cell activation. Moreover, lSuM SPW-R-active neurons show increased firing activity during theta and slow oscillations as compared to unchanged neurons. These results suggest that a sub-population of lSuM neurons can interact with the hippocampus during SPW-Rs, raising the possibility that the lSuM may modulate memory consolidation.

中文翻译:

在成年大鼠海马尖波涟漪期间,侧上颌外侧核神经生理多样性的体内表征。

尚不完全了解控制记忆整合所涉及的海马尖波波纹(SPW-Rs)的发生和调节的网络范围。在这里,我们对麻醉大鼠的θ和缓慢振荡(包括SPW-R)过程中的外侧上乳状核(lSuM)中的单细胞放电进行了详细的体内分析。我们根据神经元在SPW-R期间是否增加放电将其归类为SPW-R活跃和SPW-R不变。我们显示lSuM SPW-R活性神经元在SPW-Rs峰值功率之前和海马兴奋性细胞激活之前增加其放电。此外,与未改变的神经元相比,lSuM SPW-R活性神经元在θ期间表现出增强的放电活性,并且振荡缓慢。
更新日期:2020-03-26
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