Glycyrrhizae radix has been widely accepted as a functional food in Asia. Isoliquiritigenin is a characteristic bioactive chemical in this medicinal plant. In this work, the neuroprotective effect of isoliquiritigenin and the possible mechanisms were investigated. The results revealed that isoliquiritigenin exhibited better neuroprotective and antioxidant activities than quercetin, a commercial natural antioxidant. Isoliquiritigenin significantly inhibited the release of lactate dehydrogenase, and the generation of reactive oxygen species in H2O2-treated cells. The activities of superoxide dismutase, glutathione peroxidase and catalase were improved. The mRNA expression levels related to oxidative defense and cell apoptosis were reversed by isoliquiritigenin. Moreover, isoliquiritigenin might inhibit the cell apoptosis via ameliorating the loss of mitochondrial membrane potential and the change of nucleus morphology.

中文翻译：

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异quiritigeninin的抗氧化活性和神经保护机制。

甘草基在亚洲已被广泛接受为功能性食品。异quiritigeninin是这种药用植物中一种典型的生物活性化学品。在这项工作中，研究了异黄体苷元的神经保护作用及其可能的机制。结果表明，异黄酮皂苷元比市售天然抗氧化剂槲皮素具有更好的神经保护和抗氧化活性。异寡糖原蛋白显着抑制乳酸脱氢酶的释放以及H2O2处理的细胞中活性氧的生成。提高了超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶的活性。异黄体生成素逆转了与氧化防御和细胞凋亡相关的mRNA表达水平。此外，