After thousands of articles on solubility science (broadly including ‘similarity’ and ‘compatibility’) over the past decades, the formulator has been provided with surprisingly few tools that can help solve problems in the necessarily messy world of complex formulations. This failure of much of the academic enterprise has led to a culture of trial-and-error in formulation. Although a very few tools are of enduring value in solubility-related work, only one, currently, has a broad applicability across the range of solubility and compatibility problems faced by formulators. This tool is the Hansen Solubility Parameter (HSP) approach, which despite its many acknowledged faults and limitations is powerful and general enough to be able to guide users through formulation space with the help of on-line apps and data sets. The challenge for academics is not to fiddle with current tools but to think big and find new tools to exceed the power and generality of HSP.

在过去的几十年里，关于溶解度科学的数千篇文章（广泛地包括“相似性”和“相容性”）之后，为配方设计师提供了令人惊讶的少数工具，这些工具可以帮助解决复杂配方的必然混乱世界中的问题。许多学术事业的失败导致了制定过程中反复试验的文化。尽管很少有工具在与溶解性相关的工作中具有持久的价值，但目前只有一种工具在配方设计师面临的溶解性和相容性问题范围内具有广泛的适用性。该工具是Hansen溶解度参数（HSP）方法，尽管存在许多公认的缺点和局限性，但该工具功能强大且通用，足以借助在线应用程序和数据集指导用户完成配方空间。