Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study.,Environment International

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Associations of maternal phthalate and bisphenol urine concentrations during pregnancy with childhood blood pressure in a population-based prospective cohort study.
Environment International ( IF 11.8 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.envint.2020.105677
Chalana M Sol ₁ , Susana Santos ₁ , Alexandros G Asimakopoulos ₂ , Maria-Pilar Martinez-Moral ₃ , Liesbeth Duijts ₁ , Kurunthachalam Kannan ₄ , Leonardo Trasande ₅ , Vincent W V Jaddoe ₁

Affiliation

The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands; Department of Paediatrics, Erasmus MC - Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA; Department of Chemistry, the Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA.
Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Albany, NY 12201, USA; Biochemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Paediatrics, New York University School of Medicine, New York City, NY 10016, USA; Department of Environmental Medicine, New York University School of Medicine, New York City, NY 10016, USA; Department of Population Health, New York University School of Medicine, New York City, NY, USA; New York University Wagner School of Public Service, New York City, NY 10016, USA; New York University College of Global Public Health, New York City, NY 10016, USA.

Objectives

Fetal exposure to phthalates and bisphenols may lead to vascular developmental adaptations, which program later cardiovascular disease. We examined the associations of fetal exposure to phthalates and bisphenols with childhood blood pressure.

Methods

In a population-based, prospective cohort study among 1,064 mother-child pairs, we measured maternal urine phthalate and bisphenol concentrations in first, second and third trimester of pregnancy. We measured childhood blood pressure at the mean age of 9.7 years (standard deviation 0.2 years) old. Analyses were performed for the total group, and for boys and girls separately.

Results

Maternal urine phthalate concentrations were not associated with childhood blood pressure among boys. Higher third trimester maternal urine concentrations of high molecular weight phthalates (HMWP), di-2-ehtylhexylphthalate (DEHP) and di-n-octylphthalate (DNOP) were associated with lower systolic and diastolic blood pressure among girls (p-values < 0.01). Also, higher second trimester maternal urine total bisphenol and bisphenol A concentrations were associated with higher systolic blood pressure among boys (p values < 0.01), but tended to be associated with a lower diastolic blood pressure among girls.

Conclusions

Our results suggest sex-dependent associations of maternal urine phthalate and bisphenol concentrations during pregnancy with childhood blood pressure. Further studies are needed to explore the underlying mechanisms and long term consequences.

中文翻译：

一项基于人群的前瞻性队列研究中孕期母体邻苯二甲酸盐和双酚尿浓度与儿童血压的关联。

目标

胎儿接触邻苯二甲酸盐和双酚可能会导致血管发育适应，从而导致后来的心血管疾病。我们研究了胎儿接触邻苯二甲酸盐和双酚与儿童血压之间的关联。

方法

在一项对 1,064 对母子进行的基于人群的前瞻性队列研究中，我们测量了妊娠早期、中期和晚期的母体尿邻苯二甲酸酯和双酚浓度。我们在 9.7 岁（标准差 0.2 岁）的平均年龄测量了儿童血压。对整个组进行分析，并分别对男孩和女孩进行分析。

结果

母亲尿液邻苯二甲酸盐浓度与男孩的儿童血压无关。高分子量邻苯二甲酸酯 (HMWP)、邻苯二甲酸二-2-乙基己基酯 (DEHP) 和邻苯二甲酸二正辛酯 (DNOP) 的孕晚期母体尿液浓度较高与女孩的收缩压和舒张压较低有关（p 值 < 0.01） . 此外，较高的孕中期母体尿总双酚和双酚 A 浓度与男孩较高的收缩压有关（p 值 < 0.01），但往往与女孩较低的舒张压有关。