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Vitamin B12 Regulates Glial Migration and Synapse Formation through Isoform-Specific Control of PTP-3/LAR PRTP Expression.
Cell Reports ( IF 8.8 ) Pub Date : 2020-03-24 , DOI: 10.1016/j.celrep.2020.02.113
Albert Zhang 1 , Brian D Ackley 2 , Dong Yan 3
Affiliation  

Vitamin B12 is known to play critical roles during the development and aging of the brain, and vitamin B12 deficiency has been linked to neurodevelopmental and degenerative disorders. However, the underlying molecular mechanisms of how vitamin B12 affects the development and maintenance of the nervous system are still unclear. Here, we report that vitamin B12 can regulate glial migration and synapse formation through control of isoform-specific expression of PTP-3/LAR PRTP (leukocyte-common antigen-related receptor-type tyrosine-protein phosphatase). We found the uptake of diet-supplied vitamin B12 in the intestine to be critical for the expression of a long isoform of PTP-3 (PTP-3A) in neuronal and glial cells. The expression of PTP-3A cell autonomously regulates glial migration and synapse formation through interaction with an extracellular matrix protein NID-1/nidogen 1. Together, our findings demonstrate that isoform-specific regulation of PTP-3/ LAR PRTP expression is a key molecular mechanism that mediates vitamin-B12-dependent neuronal and glial development.

中文翻译:

维生素B12通过PTP-3 / LAR PRTP表达的亚型特异性控制来调节神经胶质迁移和突触形成。

众所周知,维生素B12在大脑的发育和衰老过程中起着至关重要的作用,维生素B12的缺乏与神经发育和退行性疾病有关。但是,维生素B12如何影响神经系统发育和维持的潜在分子机制仍不清楚。在这里,我们报道维生素B12可以通过控制PTP-3 / LAR PRTP(白细胞常见抗原相关受体型酪氨酸蛋白磷酸酶)的同工型特异性表达来调节神经胶质迁移和突触形成。我们发现摄取饮食中的肠道维生素B12对于神经元和神经胶质细胞中PTP-3(PTP-3A)长同种型的表达至关重要。
更新日期:2020-03-26
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