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Melophluosides A and B, new triterpene galactosides from the marine sponge Melophlus sarasinorum
Tetrahedron Letters ( IF 1.8 ) Pub Date : 2020-03-25 , DOI: 10.1016/j.tetlet.2020.151852
Yusaku Sadahiro , Yuki Hitora , Arina Fukumoto , Yuji Ise , Esther D. Angkouw , Remy E.P. Mangindaan , Sachiko Tsukamoto

Two new triterpene galactosides, melophluosides A and B, were isolated from a marine sponge Melophlus sarasinorum collected in Indonesia. Their structures were determined by the analysis of spectroscopic data and chemical reactions. The absolute configuration of cyclohexenone moiety was determined by the calculated ECD spectrum of a simplified model. Melophluosides A and B exhibited moderate cytotoxicity against HeLa cells (IC50, 11.6 and 9.7 µM, respectively).



中文翻译:

Melophluosides A和B,来自海洋海绵Melophlus sarasinorum的新三萜半乳糖苷

从印度尼西亚收集的一种海生海绵Melophlus sarasinorum中分离出了两种新的三萜半乳糖苷A和B。通过分析光谱数据和化学反应确定它们的结构。环己烯酮部分的绝对构型由简化模型的计算得出的ECD光谱确定。Melophluosides A和B表现出对HeLa细胞的细胞毒性适中(IC 50,11.6和9.7μM,分别地)。

更新日期:2020-03-26
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