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Aortic Aneurysms and Dissections Series: Part II: Dynamic Signaling Responses in Aortic Aneurysms and Dissections.
Arteriosclerosis, Thrombosis, and Vascular Biology ( IF 8.7 ) Pub Date : 2020-03-25 , DOI: 10.1161/atvbaha.120.313804
Ying H Shen 1, 2 , Scott A LeMaire 1, 2 , Nancy R Webb 3 , Lisa A Cassis 3 , Alan Daugherty 4 , Hong S Lu 4
Affiliation  

Aortic structure and function are controlled by the coordinated actions of different aortic cells and the extracellular matrix. Several pathways have been identified that control the aortic wall in a cell-type-specific manner and play diverse roles in various phases of aortic injury, repair, and remodeling. This complexity of signaling in the aortic wall poses challenges to the development of therapeutic strategies for treating aortic aneurysms and dissections. Here, in part II of this Recent Highlights series on aortic aneurysms and dissections, we will summarize recent studies published in Arteriosclerosis, Thrombosis, and Vascular Biology that have contributed to our knowledge of the signaling pathway-related mechanisms of aortic aneurysms and dissections.

中文翻译:

主动脉瘤和夹层系列:第二部分:主动脉瘤和夹层中的动态信号响应。

主动脉的结构和功能受不同主动脉细胞和细胞外基质的协同作用控制。已经确定了几种以细胞类型特异性方式控制主动脉壁并在主动脉损伤,修复和重塑的各个阶段发挥不同作用的途径。主动脉壁信号传递的这种复杂性对治疗主动脉瘤和夹层的治疗策略提出了挑战。在此,这是有关动脉瘤和夹层的最新摘要系列的第二部分,我们将总结动脉硬化,血栓形成和血管生物学方面发表的最新研究,这些研究有助于我们了解与动脉瘤和夹层的信号传导通路相关的机制。
更新日期:2020-03-26
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