Six new chiro-inositol derivatives (1-6) were isolated from the leaves of Chisocheton paniculatus collected in Vietnam. Their chemical structures were elucidated by 1D and 2D NMR and HRESIMS analyses. All isolated compounds were evaluated for their inhibitory activity against lipopolysaccharide-induced nitric oxide (NO) production in the RAW 264.7 macrophage cell line. Compound 4 exhibited potent inhibitory activity for NO production with an IC50 value of 7.1 μM.

中文翻译：

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Paniculatus的Chiro-肌醇衍生物，可抑制一氧化氮的产生。

从越南收集的Chisocheton paniculatus的叶子中分离出六种新的手性肌醇衍生物（1-6）。通过1D和2D NMR以及HRESIMS分析阐明了它们的化学结构。评估所有分离的化合物对RAW 264.7巨噬细胞系中脂多糖诱导的一氧化氮（NO）产生的抑制活性。化合物4对NO的产生表现出强大的抑制活性，IC50值为7.1μM。