We describe a facile strategy for building enantioenriched fluoroalkyl-substituted syn-diamines by the asymmetric gem-difunctionalization of 2,2,2-trifluorodiazoethane, which could be efficiently converted to a series of fluoroalkyl-substituted structures. The proposed key intermediate is an ammonium ylide generated from 2,2,2-trifluorodiazoethane, and its reactivity was further explored by DFT calculations.

中文翻译：

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2,2,2-三氟重氮乙烷的不对称宝石的对映选择性合成对氟烷基取代的顺二胺

我们描述了一种通过2,2,2-三氟重氮乙烷的不对称宝石-双官能化来构建对映体富集的氟烷基取代的顺式二胺的简便策略，它可以有效地转化为一系列氟烷基取代的结构。拟议的关键中间体是由2,2,2-三氟重氮乙烷生成的叶立铵，其反应性通过DFT计算得到了进一步探索。