Ras is frequently mutated in cancer, however, there is a lack of consensus in the literature regarding the cancer mutation frequency of Ras, with quoted values varying from 10%–30%. This variability is at least in part due to the selective aggregation of data from different databases and the dominant influence of particular cancer types and particular Ras isoforms within these datasets. To provide a more definitive figure for Ras mutation frequency in cancer, we cross-referenced the data in all major publicly accessible cancer mutation databases to determine reliable mutation frequency values for each Ras isoform in all major cancer types. These percentages were then applied to current U.S. cancer incidence statistics to estimate the number of new patients each year that have Ras-mutant cancers. We find that approximately 19% of patients with cancer harbor Ras mutations, equivalent to approximately 3.4 million new cases per year worldwide. We discuss the Ras isoform and mutation-specific trends evident within the datasets that are relevant to current Ras-targeted therapies.

中文翻译：

---

癌症中 Ras 突变的频率。

Ras在癌症中频繁突变，然而文献中关于Ras的癌症突变频率缺乏共识，引用值在10%~30%之间。这种变异性至少部分是由于来自不同数据库的数据的选择性聚合以及这些数据集中特定癌症类型和特定 Ras 亚型的主导影响。为了提供癌症中 Ras 突变频率的更明确的数字，我们交叉引用了所有主要可公开访问的癌症突变数据库中的数据，以确定所有主要癌症类型中每种 Ras 同工型的可靠突变频率值。然后将这些百分比应用于当前美国癌症发病率统计数据，以估计每年患有 Ras 突变癌症的新患者数量。我们发现大约 19% 的癌症患者携带 Ras 突变，相当于全球每年大约 340 万新病例。我们讨论了与当前 Ras 靶向疗法相关的数据集中明显的 Ras 亚型和突变特异性趋势。