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Visible-Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenine Anticancer Agents.
Chemistry - An Asian Journal ( IF 4.1 ) Pub Date : 2020-04-07 , DOI: 10.1002/asia.202000298
Xiu-Jie Zhou 1 , Hao-Yang Liu 1 , Zu-Yu Mo 2 , Xian-Li Ma 1 , Yan-Yan Chen 1 , Hai-Tao Tang 2 , Ying-Ming Pan 2 , Yan-Li Xu 1
Affiliation  

A metal-free and efficient visible-light-induced spirocyclization of indolyl-ynones with diselenides at room temperature under air atmosphere to prepare 3-selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell-growth inhibition activities.

中文翻译:

吲哚基-炔酮的可见光促进的烯丙基螺旋环化对3-硒代螺螺吲哚烯碱抗癌剂的形成。

在室温和大气条件下,开发了一种无金属且有效的可见光诱导的吲哚炔酮与二硒化物的螺环化反应,以中等至良好的产率制备了3-硒代螺螺吲哚。通过MTT分析测试所得产物的体外抗癌活性,并且化合物3c和3e显示出有效的癌细胞生长抑制活性。
更新日期:2020-03-23
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