The intestinal mucus layer remains a challenging biological barrier to cross for nanoformulations. We report the assembly of zwitterionic micelles with 2‐methacryloyloxyethyl phosphorylcholine as the zwitterionic entity in the corona‐forming part of the amphiphilic block copolymers. These ca. 200 nm micelles do not have inherent cytotoxicity in Caco‐2 cells for a 24 h incubation time. The time‐resolved crossing of the mucus layer in Caco‐2/HT29‐MTX‐E12 co‐cultures of these spherical micelles with narrow polydispersity is shown.

中文翻译：

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粘膜渗透性两性离子胶束

肠道粘液层仍然是纳米制剂跨越的具有挑战性的生物屏障。我们报道了在两亲性嵌段共聚物的电晕形成部分中，以2-甲基丙烯酰氧基乙基磷酰胆碱为两性离子实体的两性离子胶束的组装。这些约。200 nm胶束在24小时的孵育时间内对Caco-2细胞没有固有的细胞毒性。显示了这些球形胶束具有窄多分散性的Caco-2-HT29-MTX-E12共培养物中粘液层的时间分辨交叉。