The tuning strategies to alternatively obtain 3,4‐dihydropyrimidin‐2‐(1H )‐ones (DHPMs) and 1,4‐dihydropyridines (1,4‐DHPs), starting from the same reagents and with similar conditions, are summarized. The literature discloses the possibility of using the similarity and competition between Hantzsch and Biginelli reactions to obtain important chemical scaffolds for the pharmaceutical industry through interchangeable multicomponent reactions (MCRs).

中文翻译：

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Biginelli和Hantzsch反应之间的相似性和竞争：现代药物化学的机会

总结了从相同的试剂和相似的条件开始，交替获得3,4-二氢嘧啶-2-（1 H）-one（DHPM）和1,4-二氢吡啶（1,4-DHP）的调节策略。文献公开了通过可互换的多组分反应（MCR）利用Hantzsch反应和Biginelli反应之间的相似性和竞争性来获得制药行业重要的化学支架的可能性。