Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.

中文翻译：

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三种类型的砷脂的毒性：秀丽隐杆线虫的物种特异性作用。

尽管鱼和海鲜因其营养价值而闻名，但它们所含的污染物可能会影响人体健康。有机脂溶性砷物质，即所谓的砷脂，属于这些食品中新兴的污染物。其毒性尚待系统研究。在这里，我们应用体内的秀丽隐杆线虫模型来评估两种含砷的碳氢化合物（AsHC），饱和的含砷的脂肪酸（AsFA）和含砷的三酰甘油（AsTAG）在整个生物体内的作用。尽管在秀丽隐杆线虫中所有砷脂具有很高的生物利用度，只有AsHCs基本上被代谢为硫氧基化或缩短的代谢产物，并引起明显的毒性，从而影响生存和发育。此外，与有毒参比亚砷酸盐相比，AsHCs的效力高出几倍。这项研究明确表明需要对砷脂类亚类进行全面的危害识别，以评估它们是否对人体健康构成威胁。