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Copper-catalyzed tandem cis-carbometallation/cyclization of imine-ynamides with arylboronic acids.
Chemical Communications ( IF 4.9 ) Pub Date : 2020-04-30 , DOI: 10.1039/d0cc01424a
Hao-Ran Wang 1 , En-He Huang , Chen Luo , Wen-Feng Luo , Yin Xu , Peng-Cheng Qian , Jin-Mei Zhou , Long-Wu Ye
Affiliation  

An efficient copper-catalyzed tandem regioselective cis-carbometallation/cyclization of imine-ynamides with arylboronic acids has been developed. This method leads to a facile and practical synthesis of valuable 2,3-disubstituted indolines in moderate to excellent yields and features a broad substrate scope and wide functional group tolerance. Other significant features of this protocol include the use of readily available starting materials, high flexibility, simple procedure and mild reaction conditions.

中文翻译:

铜催化的亚胺基酰胺与芳基硼酸的串联顺式-羰基金属化/环化。

已经开发了一种有效的铜催化的串联芳基区域选择性亚胺基酰胺与顺式硼烷的顺式羰基金属化/环化反应。此方法可轻松,实用地合成有价值的2,3-二取代的二氢吲哚,产率中等至优异,并且具有广泛的底物范围和宽泛的官能团耐受性。该协议的其他重要特征包括使用容易获得的起始原料,高灵活性,简单的操作程序和温和的反应条件。
更新日期:2020-03-24
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