Lymph nodes (LNs) are strategically positioned at dedicated sites throughout the body to facilitate rapid and efficient immunity. Central to the structural integrity and framework of LNs, and the recruitment and positioning of leukocytes therein, are mesenchymal and endothelial lymph node stromal cells (LNSCs). Advances in the last decade have expanded our understanding and appreciation of LNSC heterogeneity, and the role they play in coordinating immunity has grown rapidly. In this review, we will highlight the functional contributions of distinct stromal cell populations during LN development in maintaining immune homeostasis and tolerance and in the activation and control of immune responses.

中文翻译：

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淋巴结基质细胞：免疫系统的制图师。

淋巴结（LN）战略性地定位在全身的专用部位，以促进快速有效的免疫。LNs的结构完整性和框架以及其中的白细胞募集和定位的中心是间充质和内皮淋巴结基质细胞（LNSC）。过去十年的进步扩大了我们对LNSC异质性的理解和认识，它们在协调免疫力中的作用迅速增长。在这篇综述中，我们将重点介绍LN发育过程中不同基质细胞群在维持免疫稳态和耐受性以及激活和控制免疫应答中的功能性贡献。