In past decades, interdisciplinary research has been of great interest for scholars. Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry and compel researchers to explore new drug candidates. Thiazolidine motifs are very intriguing heterocyclic five-membered moieties present in diverse natural and bioactive compounds having sulfur at the first position and nitrogen at the third position. The presence of sulfur enhances their pharmacological properties, and, therefore, they are used as vehicles in the synthesis of valuable organic combinations. They show varied biological properties viz. anticancer, anticonvulsant, antimicrobial, anti-inflammatory, neuroprotective, antioxidant activity and so on. This diversity in the biological response makes it a highly prized moiety. Based on literature studies, various synthetic approaches like multicomponent reaction, click reaction, nano-catalysis and green chemistry have been employed to improve their selectivity, purity, product yield and pharmacokinetic activity. In this review article, we have summarized systematic approaches for the synthesis of thiazolidine and its derivatives, along with their pharmacological activity, including advantages of green synthesis, atom economy, cleaner reaction profile and catalyst recovery which will help scientists to probe and stimulate the study of these scaffolds.

在过去的几十年里，跨学科研究一直引起学者们的极大兴趣。噻唑烷基序充当有机合成和药物化学之间的桥梁，并迫使研究人员探索新的候选药物。噻唑烷基序是非常有趣的杂环五元基团，存在于多种天然和生物活性化合物中，硫在第一个位置，氮在第三个位置。硫的存在增强了它们的药理特性，因此，它们被用作合成有价值的有机组合的载体。它们显示出不同的生物学特性，即。抗癌、抗惊厥、抗菌、抗炎、神经保护、抗氧化等。这种生物反应的多样性使其成为一个备受推崇的部分。根据文献研究，已采用多种合成方法，如多组分反应、点击反应、纳米催化和绿色化学，以提高其选择性、纯度、产物收率和药代动力学活性。在这篇综述文章中，我们总结了噻唑烷及其衍生物合成的系统方法，以及它们的药理活性，包括绿色合成、原子经济、更清洁的反应曲线和催化剂回收等优势，这将有助于科学家探索和促进研究这些脚手架。