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A Notch in Time: Spatiotemporal Analysis of Notch Signaling during Pancreas Development
Developmental Cell ( IF 11.8 ) Pub Date : 2020-03-23 , DOI: 10.1016/j.devcel.2020.02.018
David S. Lorberbaum , Lori Sussel

Notch signaling is a major regulator of pancreas development, yet how it precisely controls pancreatic cell fates has remained obscure. Seymour et al. (2020) use sophisticated Notch- based genetic tools to uncover highly context- and temporally-specific roles for DLL1, JAG1, and HES1 in regulating pancreatic progenitor cell growth and specification.



中文翻译:

时间上的缺口:胰腺发育过程中缺口信号的时空分析

Notch信号是胰腺发育的主要调节因子,但如何精确控制胰腺细胞的命运仍不清楚。Seymour等。(2020年)使用复杂的基于Notch的遗传工具来揭示DLL1,JAG1和HES1在调节胰腺祖细胞生长和规格方面的高度特定于上下文和时间的作用。

更新日期:2020-03-24
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