To achieve 3D printing scaffolds for bone tissue repairing, suitable consumables are the prerequisite requirement. However, though various bone repair scaffolds were prepared, there were few clinical applications owing to their poor mechanical performances and limited osteogenic activity. In this study, a novel 3D printing composite consumable consisting of poly (l-lactide) (PLLA) matrix, surface grafted MgO whiskers (gMgOs) and halloysite nanotubes (gHNTs) was developed. This design can fully combine the printability of PLLA, the excellent osteogenic activity of gMgOs and the outstanding reinforcement and toughening effect of gHNTs. Using such consumables, the porous gHNTs/gMgOs/PLLA composite scaffolds with large and small pores and honeycomb structure were further fabricated by 3D printing. The synergetic presence of gMgOs and gHNTs can endow the as-prepared composite scaffolds with obviously enhanced hydrophilicity, tensile and compressive properties, as well as cell affinity and osteogenic activity. Moreover, gMgOs and gHNTs play different roles in improving the performance of the composite scaffold. The gHNTs can effectively improve the mechanical properties of the scaffolds, while the gMgOs were more beneficial to mouse embryo osteoblast precursor (MC3T3-E1) cells adhesion, proliferation, migration and secretion of ALP activity and calcium depositions on the scaffolds.

为了获得用于骨组织修复的3D打印支架，先决条件是需要合适的消耗品。然而，尽管制备了各种骨修复支架，但是由于它们的机械性能差和成骨活性有限，因此很少有临床应用。在这项研究中，开发了一种新型3D打印复合材料，该复合材料由聚（l-丙交酯）（PLLA）基质，表面接枝的MgO晶须（g MgOs）和埃洛石纳米管（g HNTs）组成。这样的设计可以充分结合PLLA，的优秀成骨活性的印刷适性摹MgOs和优秀的增强增韧效果摹HNTS。使用此类耗材，多孔g HNT /通过3D打印进一步制造了具有大孔和小孔以及蜂窝状结构的g MgOs / PLLA复合支架。g MgOs和g HNTs的协同存在可以使所制备的复合支架具有明显增强的亲水性，拉伸和压缩特性，以及细胞亲和力和成骨活性。此外，克MgOs和克HNTS在提高复合支架的性能扮演不同的角色。所述克HNTS能有效地提高支架的机械性能，而克MgOs对小鼠胚胎成骨细胞前体（MC3T3-E1）细胞粘附，ALP活性的增殖，迁移和分泌以及钙在支架上的沉积更有利。