Oral infections are common among individuals of all ages and can activate local and systemic inflammation. The inflammatory response plays an important role in atherosclerosis. An increasing number of studies have reported an association between oral pathogen infection and atherosclerotic coronary heart disease. For instance, epidemiological studies support the positive correlation between oral infections and atherosclerosis. The presence of oral pathogens in human atherosclerotic plaques has been detected by multiple methods, and oral infections promote atherosclerosis in animal experiments. Various mechanisms are involved in oral infections, thereby promoting atherosclerosis. First, oral infections can trigger the local and systemic inflammatory response, causing vascular endothelial damage. Oral-derived pathogens that enter atherosclerotic plaque can activate macrophages and cause an intra-plaque inflammatory response. Second, oral infections can promote intra-plaque macrophage cholesterol accumulation and foam cell formation. Third, oral infections can regulate plasma lipid levels, thereby increasing atherogenic lipid low-density lipoprotein and triglyceride levels. Although atherosclerosis caused by oral infections is currently studied, the precise mechanism remains to be further explored. The rise of gut microbiota research also makes the relationship between oral microbiota and disease, especially the relationship with coronary heart disease, worthy of attention and in-depth research.

中文翻译：

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口腔微生物群在动脉粥样硬化中的作用。

口腔感染在所有年龄段的人中都很常见，并且可以激活局部和全身性炎症。炎症反应在动脉粥样硬化中起重要作用。越来越多的研究报告了口腔病原体感染与动脉粥样硬化性冠心病之间的关联。例如，流行病学研究支持口腔感染与动脉粥样硬化之间的正相关。已经通过多种方法检测到人类动脉粥样斑块中口腔病原体的存在，并且在动物实验中口腔感染促进了动脉粥样硬化。口腔感染涉及多种机制，从而促进动脉粥样硬化。首先，口腔感染可触发局部和全身性炎症反应，引起血管内皮损伤。进入动脉粥样硬化斑块的口服病原体可以激活巨噬细胞并引起斑块内炎症反应。其次，口腔感染可促进斑块内巨噬细胞胆固醇积累和泡沫细胞形成。第三，口腔感染可调节血浆脂质水平，从而增加动脉粥样硬化性脂质低密度脂蛋白和甘油三酸酯的水平。尽管目前正在研究由口腔感染引起的动脉粥样硬化，但其确切机制仍有待进一步探索。肠道菌群研究的兴起也使得口腔菌群与疾病的关系，尤其是与冠心病的关系，值得关注和深入研究。口腔感染可促进斑块内巨噬细胞胆固醇积累和泡沫细胞形成。第三，口腔感染可调节血浆脂质水平，从而增加动脉粥样硬化性脂质低密度脂蛋白和甘油三酸酯的水平。尽管目前正在研究由口腔感染引起的动脉粥样硬化，但其确切机制仍有待进一步探索。肠道菌群研究的兴起也使得口腔菌群与疾病的关系，特别是与冠心病的关系，值得关注和深入研究。口腔感染可促进斑块内巨噬细胞胆固醇积累和泡沫细胞形成。第三，口腔感染可调节血浆脂质水平，从而增加动脉粥样硬化性脂质低密度脂蛋白和甘油三酸酯的水平。尽管目前正在研究由口腔感染引起的动脉粥样硬化，但其确切机制仍有待进一步探索。肠道菌群研究的兴起也使得口腔菌群与疾病的关系，尤其是与冠心病的关系，值得关注和深入研究。确切的机制还有待进一步探索。肠道菌群研究的兴起也使得口腔菌群与疾病的关系，尤其是与冠心病的关系，值得关注和深入研究。确切的机制还有待进一步探索。肠道菌群研究的兴起也使得口腔菌群与疾病的关系，尤其是与冠心病的关系，值得关注和深入研究。