The prevalence of obesity and associated diseases has reached pandemic levels. Obesity is often associated with overnutrition and a sedentary lifestyle, but clearly other factors also increase the susceptibility of metabolic disease states. Ancestral and direct exposures to environmental toxicants and altered nutrition have been shown to increase susceptibility for obesity and metabolic dysregulation. Environmental insults can reprogram the epigenome of the germline (sperm and eggs), which transmits the susceptibility for disease to future generations through epigenetic transgenerational inheritance. In this review, we discuss current evidence and molecular mechanisms for epigenetic transgenerational inheritance of obesity susceptibility. Understanding ancestral environmental insults and epigenetic transgenerational impacts on future generations will be critical to fully understand the etiology of obesity and to develop preventative therapy options.

中文翻译：

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肥胖易感性的表观遗传跨代遗传

肥胖症和相关疾病的流行已达到大流行水平。肥胖通常与营养过剩和久坐不动的生活方式有关，但显然其他因素也会增加代谢疾病状态的易感性。祖先和直接暴露于环境毒物和改变的营养已被证明会增加肥胖和代谢失调的易感性。环境侮辱可以重新编程生殖系（精子和卵子）的表观基因组，通过表观遗传跨代遗传将疾病易感性传递给后代。在这篇综述中，我们讨论了肥胖易感性表观遗传跨代遗传的当前证据和分子机制。