Convenient synthesis of a new family of chiral ferrocene/indole-based diphosphine ligands, (R_c,R_p)-IndoFerroPhos (L), from (S_c,R_p)-PPFA and 2-(diphenylphosphino)indole has been described. These new ligands exhibited high efficiency in the Rh-catalyzed asymmetric hydrogenation of functionalized olefins including α-dehydroamino acid esters, α-enamides and dimethyl itaconate, in which up to >99% yield and 98% ee were achieved.

中文翻译：

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用于Rh催化官能化烯烃不对称氢化的新型手性二茂铁/吲哚基二膦配体

已经描述了从（S _c，R _p）-PPFA和2-（二苯基膦基）吲哚方便地合成新的手性二茂铁/吲哚基二膦配体家族（R _c，R _p）-IndoFerroPhos（L）。这些新的配体在Rh催化的功能化烯烃（包括α-脱氢氨基酸酯，α-烯酰胺和衣康酸二甲酯）的Rh催化不对称氢化中表现出很高的效率，其中产率高达99％以上，ee达到98％。