Protein prenylation, a well-defined protein consensus motifs direct modification by one of three prenyl-transferases, has been an area of fairly settled science for 20 or 30 years. Protein prenylation, the specific prenyl modification (farnesyl or geranylgeranyl), as well as the prenyl-transferases involved can be inferred by protein sequence. Two new papers now upset this settled wisdom with the discovery of a fourth prenyl-transferase, namely geranylgeranyl-transferase-III (GGTase-III) (Kuchay et al, 2019; Shirakawa et al, 2020).

中文翻译：

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Geranylgeranyl慷慨：一种新的异戊二烯基转移酶为SNARE蛋白增添了脂肪。

蛋白质异戊二烯化是由三种异戊二烯基转移酶之一直接修饰的明确定义的蛋白质共有基序，已经有20到30年的科学历史了。蛋白质序列可以推断出蛋白质异戊烯基化，特定的异戊二烯基修饰（法呢基或香叶基香叶基）以及所涉及的异戊二烯基转移酶。现在有两篇新论文发现了第四个异戊二烯基转移酶，即香叶基香叶基转移酶-III（GGTase-III）（Kuchay等，2019; Shirakawa等，2020）。