No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML). We studied defined events in 818 adult patients with AML in relation to 60,209 CRP and PA measures. We investigated correlations between CRP and PA levels and daily CRP and PA levels in relation to AML diagnosis, AML relapse, or bacteraemia (all ±30 days), and death (─30–0 days). On the AML diagnosis date (D0), CRP levels increased with higher WHO performance score (PS), e.g. patients with PS 3/4 had 68.1 mg/L higher CRP compared to patients with PS 0, adjusted for relevant covariates. On D0, the PA level declined with increasing PS, e.g. PS 3/4 had 7.54 g/L lower adjusted PA compared to PS 0. CRP and PA levels were inversely correlated for the PA interval 25–55 g/L (R = − 0.51, p < 10–5), but not for ≤24 g/L (R = 0.01, p = 0.57). CRP increases and PA decreases were seen prior to bacteraemia and death, whereas no changes occurred up to AML diagnosis or relapse. CRP increases and PA decreases were also found frequently in individuals, unrelated to a pre-specified event. PA decrease is an important biomarker for imminent bacteraemia in adult patients with AML.

中文翻译：

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急性髓性白血病患者的诊断，复发，菌血症和死亡周围的血浆白蛋白和C反应蛋白水平的纵向轨迹模式

尚无研究纵向评估急性髓细胞性白血病（AML）患者的C反应蛋白（CRP）和血浆白蛋白（PA）水平。我们研究了818名成年AML患者与60,209个CRP和PA指标相关的明确事件。我们调查了CRP和PA水平与每日CRP和PA水平之间与AML诊断，AML复发或菌血症（均为±30天）和死亡（─30-0天）之间的相关性。在AML诊断日期（D0），CRP水平随WHO评分更高（PS）而升高，例如，经相关协变量调整后，PS 3/4的患者的CRP比PS 0的患者高68.1 mg / L。在D0时，PA含量随PS的增加而下降，例如PS 3/4的PS相对于PS 0降低了7.54 g /L。CRP和PA含量在25-55 g / L的PA区间呈负相关（R =- 0.51，p <10–5），但对于≤24g / L则不适用（R = 0.01，p = 0.57）。在菌血症和死亡之前，CRP升高而PA降低，而在AML诊断或复发之前未发生任何变化。个人中也经常发现CRP升高和PA降低，与预先指定的事件无关。PA降低是成人AML患者即将发生菌血症的重要生物标志物。