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A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota
Journal of Agricultural and Food Chemistry ( IF 6.1 ) Pub Date : 2020-03-30 , DOI: 10.1021/acs.jafc.0c01414
Chunxiao Ren 1 , Yijiang Wang 1 , Xiaofeng Lin 1 , Hanqing Song 1 , Qiqi Zhou 1 , Wan Xu 1 , Kui Shi 1 , Jun Chen 1 , Junshuai Song 1 , Fang Chen 1 , Shihai Zhang 1, 2 , Wutai Guan 1, 2
Affiliation  

This study determined the potential of formic acid plus monolaurin (FA + ML) as an alternative to antibiotics in diet when piglets are challenged with ETEC. Piglets fed the FA + ML diet had lower fecal score and rectal temperature after the ETEC challenge. In addition, FA + ML supplementation induced lower plasma TNF-α, IL-6, and IL-1β concentration postchallenge, downregulated the mRNA expression of TNF-α, IL-1β, IL-6, and TLR4 in the ileum and TLR4 and CFTR in the jejunum. Phosphorylation levels of NF-κB p65 and MAPK p38 were reduced in the ileum of piglets fed FA + ML diet. Supplementation of FA + ML increased the relative abundance of genera Lactobacillus especially Lactobacillus amylovorus species and decreased the genus abundances of Actinobacillus, unidentified Enterobacteriaceae, Moraxella. Collectively, the combination of formic acid and monolaurin in diets have the potential to be an antibiotic alternative to mitigate inflammatory response in piglets challenged with ETEC.

中文翻译:

甲酸和月桂酸酯的组合通过抑制肠道微生物群的调节来抑制NF-κB/ MAPK途径,从而减轻肠毒素性大肠杆菌诱导的仔猪肠道炎症。

这项研究确定了当仔猪受到ETEC攻击时,甲酸加月桂酸酯(FA + ML)可以替代日粮中的抗生素。在接受ETEC攻击后,以FA + ML日粮喂养的仔猪粪便评分和直肠温度较低。此外,FA + ML补充可激发攻击后血浆TNF-α,IL-6和IL-1β的较低浓度,下调回肠和TLR4中TNF-α,IL-1β,IL-6和TLR4的mRNA表达。空肠中的CFTR。饲喂FA + ML日粮的仔猪回肠中NF-κBp65和MAPK p38的磷酸化水平降低。补充FA + ML增加了杆菌属(尤其是淀粉乳杆菌)的相对丰度,降低了放线杆菌的属丰度,不明肠杆菌科莫拉氏杆菌。总体而言,日粮中甲酸和月桂酸酯的组合有可能成为抗生素替代品,以减轻受到ETEC攻击的仔猪的炎症反应。
更新日期:2020-03-30
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