当前位置:
X-MOL 学术
›
Anal. Chem.
›
论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
A High-Fidelity Electrochemical Platform Based on Au-Se Interface for Biological Detection.
Analytical Chemistry ( IF 7.4 ) Pub Date : 2020-04-01 , DOI: 10.1021/acs.analchem.9b05509 Yanzheng Chen 1 , Xiaoting Song 1 , Lu Li 1 , Bo Tang 1
Analytical Chemistry ( IF 7.4 ) Pub Date : 2020-04-01 , DOI: 10.1021/acs.analchem.9b05509 Yanzheng Chen 1 , Xiaoting Song 1 , Lu Li 1 , Bo Tang 1
Affiliation
Gold (Au) electrodes are one of the most ideal electrodes and are extensively used to construct electrochemical biological detection platforms. The electrode-molecule interface between the Au electrode and biomolecules is critical to the stability and efficiency of the detection platform. However, traditional Au-sulfur (Au-S) interfaces experience distortion due to high levels of glutathione (GSH) and other biological thiols in biological samples as well as a high charge barrier when electrons are injected into the biomolecule from the Au electrode. In view of the higher bonding energy of Au-selenium (Au-Se) bonds than those of Au-S bonds and the elevated Fermi energy of the Au electrodes when Au-Se bonds are formed instead of Au-S bonds at the interface between the electrodes and molecules, we establish a new type of electrochemical platform based on the Au-Se interface (Au-Se electrochemical platform) for high-fidelity biological detection. Compared with that of the electrochemical platform based on the Au-S interface (Au-S electrochemical platform), the Au-Se electrochemical platform shows a higher charge transfer rate and excellent stability in millimolar levels of GSH. The Au-Se electrochemical platform supplies an ideal solution for accurate biological detection and has great potential in biomedical detection applications.
中文翻译:
基于Au-Se接口的高保真电化学平台用于生物检测。
金(Au)电极是最理想的电极之一,被广泛用于构建电化学生物检测平台。金电极和生物分子之间的电极-分子界面对于检测平台的稳定性和效率至关重要。但是,由于电子样品中的谷胱甘肽(GSH)和其他生物硫醇含量很高,传统的金-硫(Au-S)界面会发生变形,而且当电子从金电极注入生物分子时,电荷阻挡层也很高。鉴于金-硒(Au-Se)键的键能比Au-S键的键能高,并且当形成Au-Se键而不是Au-S键时,Au电极的费米能量升高电极和分子,我们基于Au-Se界面(Au-Se电化学平台)建立了一种用于高保真生物检测的新型电化学平台。与基于Au-S界面的电化学平台(Au-S电化学平台)相比,Au-Se电化学平台在GSH的毫摩尔水平上显示出更高的电荷转移速率和出色的稳定性。Au-Se电化学平台为精确的生物检测提供了理想的解决方案,在生物医学检测应用中具有巨大的潜力。Au-Se电化学平台在毫摩尔水平的GSH中显示出更高的电荷转移速率和出色的稳定性。Au-Se电化学平台为精确的生物检测提供了理想的解决方案,在生物医学检测应用中具有巨大的潜力。Au-Se电化学平台在毫摩尔水平的GSH中显示出更高的电荷转移速率和出色的稳定性。Au-Se电化学平台为精确的生物检测提供了理想的解决方案,在生物医学检测应用中具有巨大的潜力。
更新日期:2020-04-23
中文翻译:
基于Au-Se接口的高保真电化学平台用于生物检测。
金(Au)电极是最理想的电极之一,被广泛用于构建电化学生物检测平台。金电极和生物分子之间的电极-分子界面对于检测平台的稳定性和效率至关重要。但是,由于电子样品中的谷胱甘肽(GSH)和其他生物硫醇含量很高,传统的金-硫(Au-S)界面会发生变形,而且当电子从金电极注入生物分子时,电荷阻挡层也很高。鉴于金-硒(Au-Se)键的键能比Au-S键的键能高,并且当形成Au-Se键而不是Au-S键时,Au电极的费米能量升高电极和分子,我们基于Au-Se界面(Au-Se电化学平台)建立了一种用于高保真生物检测的新型电化学平台。与基于Au-S界面的电化学平台(Au-S电化学平台)相比,Au-Se电化学平台在GSH的毫摩尔水平上显示出更高的电荷转移速率和出色的稳定性。Au-Se电化学平台为精确的生物检测提供了理想的解决方案,在生物医学检测应用中具有巨大的潜力。Au-Se电化学平台在毫摩尔水平的GSH中显示出更高的电荷转移速率和出色的稳定性。Au-Se电化学平台为精确的生物检测提供了理想的解决方案,在生物医学检测应用中具有巨大的潜力。Au-Se电化学平台在毫摩尔水平的GSH中显示出更高的电荷转移速率和出色的稳定性。Au-Se电化学平台为精确的生物检测提供了理想的解决方案,在生物医学检测应用中具有巨大的潜力。