Efficient removal of deadly toxicants by blood purification remains predominant in poisoning treatment. Current strategies mainly rely on absorptive scavengers that normally have no selectivity to the adsorbates, which could result poor clinical outcomes to certain toxic species due to the passivity and inaccuracy of the detoxification procedure. Herein, a positive, accurate, and customized detoxification strategy was proposed. Based on the sophisticated molecule design and thoughtful structure analysis of the aimed toxicant paraquat, a supramolecular hunter stationed on red blood cells (RBC) is developed to continuously track paraquat in the blood. In this construct, a Janus dendrimer amphiphile (JDA) molecule was synthesized with the aim of facilely anchoring onto RBC membranes while bridging to load the antidote WP6 that could precisely recognize paraquat. In vitro and in vivo results demonstrate the effective toxicant-hunting and harm-neutralizing capability of the system through a guest-exchange reaction. This strategy provides a different insight in designing scavengers that can actively, precisely, and continuously hunt toxicants through a supramolecular approach.

中文翻译：

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基于特定分子识别的超分子猎人驻扎在红细胞上进行解毒。

通过血液净化有效去除致命的毒物仍然是中毒治疗的主要内容。当前的策略主要依靠通常对吸附物没有选择性的吸收性清除剂，由于排毒程序的被动性和不准确性，这可能导致对某些有毒物种的不良临床结果。在此，提出了一种积极，准确，定制的排毒策略。基于目标毒物百草枯的精密分子设计和周到的结构分析，开发了一种驻扎在红血球（RBC）上的超分子猎人来连续追踪血液中的百草枯。在这个结构中 合成了Janus树状聚合物两亲（JDA）分子，目的是轻松锚定到RBC膜上，同时桥接以加载可以精确识别百草枯的解毒剂WP6。体外和体内结果表明，通过客体交换反应，该系统具有有效的捕毒和中和伤害的能力。这种策略在设计清除剂方面提供了不同的见解，这些清除剂可以通过超分子方法主动，精确和连续地捕集有毒物质。