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Metal‐Free Direct C–H β‐Carbonyl Alkylation of Heteroarenes with Cyclopropanols Mediated by K2S2O8
European Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-04-20 , DOI: 10.1002/ejoc.202000289
Qiang Liu 1, 2 , Qiang Wang 1, 2 , Guanqun Xie 1 , Zeyang Fang 1 , Shujiang Ding 2 , Xiaoxia Wang 1
Affiliation  

A metal‐free direct C–H β‐carbonyl alkylation of heteroarenes has been achieved through K2S2O8‐mediated ring‐opening of cyclopropanols. A wide scope of substrates, such as various substituted quinolines and isoquinolines, pyridines, pyridazine, benzo[d]thiazole, and phenanthroline, underwent the β‐carbonyl alkylation efficiently and afforded the β‐heteroarylated ketones in moderate to excellent yields.
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中文翻译:

K2S2O8介导的杂芳烃与环丙醇的无金属直接C–Hβ-羰基烷基化

无金属直接C-H β羰基杂芳烃烷基化已到K达到2小号2 ö 8介导的cyclopropanols的开环。各种各样的底物,例如各种取代的喹啉和异喹啉,吡啶,哒嗪,苯并[d]噻唑和菲咯啉,有效地进行了β羰基烷基化反应,并以中等至优异的产率提供了β杂芳基化的酮。
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更新日期:2020-04-20
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