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BoLA-DRB3 Polymorphism is Associated with Differential Susceptibility to Bovine Leukemia Virus-Induced Lymphoma and Proviral Load.
Viruses ( IF 5.818 ) Pub Date : 2020-03-22 , DOI: 10.3390/v12030352 Chieh-Wen Lo 1, 2, 3 , Liushiqi Borjigin 2, 4 , Susumu Saito 2, 3, 5 , Koya Fukunaga 6 , Etsuko Saitou 7 , Katsunori Okazaki 8 , Tetsuya Mizutani 5 , Satoshi Wada 3 , Shin-Nosuke Takeshima 2, 3, 9 , Yoko Aida 1, 2, 4, 5
Viruses ( IF 5.818 ) Pub Date : 2020-03-22 , DOI: 10.3390/v12030352 Chieh-Wen Lo 1, 2, 3 , Liushiqi Borjigin 2, 4 , Susumu Saito 2, 3, 5 , Koya Fukunaga 6 , Etsuko Saitou 7 , Katsunori Okazaki 8 , Tetsuya Mizutani 5 , Satoshi Wada 3 , Shin-Nosuke Takeshima 2, 3, 9 , Yoko Aida 1, 2, 4, 5
Affiliation
Bovine leukemia virus (BLV) is the causative agent of enzootic bovine leucosis. However, less than 5% of BLV-infected cattle will develop lymphoma, suggesting that, in addition to viral infection, host genetic polymorphisms might play a role in disease susceptibility. Bovine leukocyte antigen (BoLA)-DRB3 is a highly polymorphic gene associated with BLV proviral load (PVL) susceptibility. Due to the fact that PVL is positively associated with disease progression, it is believed that controlling PVL can prevent lymphoma development. Thus, many studies have focused on the relationship between PVL and BoLA-DRB3. Despite this, there is little information regarding the relationship between lymphoma and BoLA-DRB3. Furthermore, whether or not PVL-associated BoLA-DRB3 is linked to lymphoma-associated BoLA-DRB3 has not been clarified. Here, we investigated whether or not lymphoma-associated BoLA-DRB3 is correlated with PVL-associated BoLA-DRB3. We demonstrate that two BoLA-DRB3 alleles were specifically associated with lymphoma resistance (*010:01 and *011:01), but no lymphoma-specific susceptibility alleles were found; furthermore, two other alleles, *002:01 and *012:01, were associated with PVL resistance and susceptibility, respectively. In contrast, lymphoma and PVL shared two resistance-associated (DRB3*014:01:01 and *009:02) BoLA-DRB3 alleles. Interestingly, we found that PVL associated alleles, but not lymphoma associated alleles, are related with the anti-BLV gp51 antibody production level in cows. Overall, our study is the first to demonstrate that the BoLA-DRB3 polymorphism confers differential susceptibility to BLV-induced lymphoma and PVL.
中文翻译:
BoLA-DRB3多态性与牛白血病病毒诱导的淋巴瘤和前病毒载量的易感性相关。
牛白血病病毒(BLV)是牛源性牛白血病的病原体。然而,少于5%的受BLV感染的牛会发展淋巴瘤,这表明,除病毒感染外,宿主遗传多态性可能在疾病易感性中起作用。牛白细胞抗原(BoLA)-DRB3是与BLV前病毒载量(PVL)易感性相关的高度多态性基因。由于PVL与疾病进展呈正相关,因此认为控制PVL可以预防淋巴瘤的发展。因此,许多研究集中于PVL与BoLA-DRB3之间的关系。尽管如此,关于淋巴瘤与BoLA-DRB3之间关系的信息很少。此外,尚不清楚PVL相关的BoLA-DRB3是否与淋巴瘤相关的BoLA-DRB3连接。这里,我们调查了淋巴瘤相关的BoLA-DRB3是否与PVL相关的BoLA-DRB3相关。我们证明了两个BoLA-DRB3等位基因与淋巴瘤耐药性相关(* 010:01和* 011:01),但未发现淋巴瘤特异性易感性等位基因。此外,另外两个等位基因* 002:01和* 012:01分别与PVL耐药性和易感性相关。相反,淋巴瘤和PVL共有两个抗药性相关的(DRB3 * 014:01:01和* 009:02)BoLA-DRB3等位基因。有趣的是,我们发现与PVL相关的等位基因,与与淋巴瘤相关的等位基因无关,与母牛抗BLV gp51抗体的产生水平有关。总体而言,我们的研究首次证明BoLA-DRB3多态性赋予BLV诱导的淋巴瘤和PVL不同的易感性。
更新日期:2020-03-22
中文翻译:
BoLA-DRB3多态性与牛白血病病毒诱导的淋巴瘤和前病毒载量的易感性相关。
牛白血病病毒(BLV)是牛源性牛白血病的病原体。然而,少于5%的受BLV感染的牛会发展淋巴瘤,这表明,除病毒感染外,宿主遗传多态性可能在疾病易感性中起作用。牛白细胞抗原(BoLA)-DRB3是与BLV前病毒载量(PVL)易感性相关的高度多态性基因。由于PVL与疾病进展呈正相关,因此认为控制PVL可以预防淋巴瘤的发展。因此,许多研究集中于PVL与BoLA-DRB3之间的关系。尽管如此,关于淋巴瘤与BoLA-DRB3之间关系的信息很少。此外,尚不清楚PVL相关的BoLA-DRB3是否与淋巴瘤相关的BoLA-DRB3连接。这里,我们调查了淋巴瘤相关的BoLA-DRB3是否与PVL相关的BoLA-DRB3相关。我们证明了两个BoLA-DRB3等位基因与淋巴瘤耐药性相关(* 010:01和* 011:01),但未发现淋巴瘤特异性易感性等位基因。此外,另外两个等位基因* 002:01和* 012:01分别与PVL耐药性和易感性相关。相反,淋巴瘤和PVL共有两个抗药性相关的(DRB3 * 014:01:01和* 009:02)BoLA-DRB3等位基因。有趣的是,我们发现与PVL相关的等位基因,与与淋巴瘤相关的等位基因无关,与母牛抗BLV gp51抗体的产生水平有关。总体而言,我们的研究首次证明BoLA-DRB3多态性赋予BLV诱导的淋巴瘤和PVL不同的易感性。