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Attenuation of noisy environment-induced neuroinflammation and dysfunction of learning and memory by minocycline during perioperative period in mice.
Brain Research Bulletin ( IF 3.8 ) Pub Date : 2020-03-21 , DOI: 10.1016/j.brainresbull.2020.03.004
Fei Lin 1 , Yuxin Zheng 2 , Linghui Pan 3 , Zhiyi Zuo 4
Affiliation  

Noisy environment often occurs in hospitals. We set out to determine whether noisy environment induces neuroinflammation and impairment of learning and memory and whether the effects of noise contribute to the development of neuroinflammation and impairment of learning and memory during the perioperative period. Seven-week old CD-1 male mice were exposed to noisy environment in the presence or absence of surgery (right carotid artery exposure). Noisy environment was 75 db, 6 h/day, for 3 days or 5 days. Minocycline (40 mg/kg), an antibiotic with anti-inflammatory property, was administered intraperitoneally 1 h before surgery or each episode of noise. The learning and memory of mice were assessed by Barnes maze and fear conditioning tests. Brain was harvested for the determination of interleukin (IL)-1β and IL-6 and for immunohistochemical staining. We found that noise induced learning and memory impairment. Noise also increased IL-1β, IL-6 and ionized calcium binding adapter molecule 1 (Iba-1) in the hippocampus. The combination of noisy environment and surgery induced dysfunction of additional domains of learning and memory and a higher expression of Iba-1 in the hippocampus. The effects of noisy environment or the combination of noisy environment and surgery were attenuated by minocycline. These findings suggest that noisy environment induces neuroinflammation and impairment of learning and memory. These effects may contribute to the development of neuroinflammation and dysfunction of learning and memory during the perioperative period. Neuroinflammation may be an underlying pathophysiological process for cognitive dysfunction induced by noise or the combination of noise and surgery. Minocycline may be effective in attenuating these noise-induced effects.

中文翻译:

米诺环素对小鼠围手术期噪声环境诱导的神经炎症和学习记忆功能障碍的减弱作用。

嘈杂的环境经常发生在医院。我们着手确定嘈杂的环境是否会诱发神经炎症和学习记忆障碍,以及噪音的影响是否有助于围手术期神经炎症的发展和学习记忆障碍。七周大的 CD-1 雄性小鼠在有或没有手术(右颈动脉暴露)的情况下暴露在嘈杂的环境中。噪音环境为 75 分贝,6 小时/天,持续 3 天或 5 天。米诺环素 (40 mg/kg) 是一种具有抗炎特性的抗生素,在手术前 1 小时或每次出现噪音时腹膜内给药。通过巴恩斯迷宫和恐惧条件反射测试评估小鼠的学习和记忆能力。收集大脑用于测定白细胞介素 (IL)-1β 和 IL-6 以及用于免疫组织化学染色。我们发现噪音会导致学习和记忆障碍。噪音还会增加海马体中的 IL-1β、IL-6 和离子钙结合接头分子 1 (Iba-1)。嘈杂的环境和手术的结合导致了额外的学习和记忆领域的功能障碍以及海马中 Iba-1 的更高表达。嘈杂环境或嘈杂环境与手术结合的影响被米诺环素减弱。这些发现表明,嘈杂的环境会诱发神经炎症和学习记忆障碍。这些影响可能导致围手术期神经炎症和学习记忆功能障碍的发展。神经炎症可能是噪声或噪声与手术结合引起的认知功能障碍的潜在病理生理过程。米诺环素可能有效减轻这些噪音引起的影响。
更新日期:2020-03-22
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