Octenyl-succinylated inulins (OSA-inulin) were synthesized in aqueous solutions using inulin with varying degrees of polymerization (DP). They were characterized using ¹H NMR and FTIR and their degrees of substitution were determined. All the samples formed micellar aggregates in aqueous solution above a critical aggregation concentration (CAC) and solubilized beta-carotene. The amount of beta carotene solubilized within the micelles ranged from 12 -25 mg/g of OSA-inulin and depended on the inulin molar mass. Dynamic light scattering showed that the aggregates, with and without dissolved beta-carotene, were ∼10-15 nm in size and this was confirmed by Transmission Electron Microscopy which also indicated that the micelles had a globular shape. OSA-inulin particles containing encapsulated beta-carotene were produced by freeze-drying. The encapsulated beta-carotene was not released from the freeze-dried particles when introduced into simulated gastric fluid at pH 2.5 but was readily released in simulated small intestinal fluid at pH 7. The results demonstrate the potential application of OSA-inulin in the encapsulation, dissolution and targeted delivery of hydrophobic drug molecules for nutraceutical, pharmaceutical and medical applications.

使用具有不同聚合度（DP）的菊粉在水溶液中合成辛烯基琥珀酰菊粉（OSA-菊粉）。使用¹来表征测定1 H NMR和FTIR及其取代度。所有样品均在高于临界聚集浓度（CAC）和可溶性β-胡萝卜素的水溶液中形成胶束聚集体。溶于胶束中的β-胡萝卜素的量为12 -25 mg / g OSA-菊粉，并取决于菊粉的摩尔质量。动态光散射表明，具有和不具有溶解的β-胡萝卜素的聚集体的尺寸为〜10-15nm，这通过透射电子显微镜证实，其还表明胶束具有球形的形状。通过冷冻干燥产生包含包封的β-胡萝卜素的OSA-菊粉颗粒。将胶囊化的β-胡萝卜素引入pH为2的模拟胃液时不会从冻干颗粒中释放出来。