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The multifunctional nature of mitochondrial contact site proteins.
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2020-03-21 , DOI: 10.1016/j.ceb.2020.02.010
Clare S Harper 1 , Antoineen J White 1 , Laura L Lackner 1
Affiliation  

Mitochondria make physical contact with nearly every other membrane in the cell, and these contacts have a wide variety of functions that are carried out by proteins that reside at the sites of contact. Over the past decade, tremendous insight into the identity and functions of proteins localized to mitochondrial contact sites has been gained. In doing so, it has become clear that one protein or protein complex can contribute to contact site formation and function in a wide variety of ways. Thus, complex and often surprising relationships between the roles of a mitochondrial contact site and its multifunctional resident proteins continue to be unraveled.

中文翻译:

线粒体接触位点蛋白的多功能性质。

线粒体与细胞中几乎所有其他膜进行物理接触,这些接触具有多种功能,这些功能由位于接触部位的蛋白质执行。在过去的十年中,人们对定位于线粒体接触位点的蛋白质的身份和功能有了深入的了解。在这样做时,很明显一种蛋白质或蛋白质复合物可以以多种方式促进接触位点的形成和功能。因此,线粒体接触位点的作用与其多功能驻留蛋白之间的复杂且经常令人惊讶的关系继续被解开。
更新日期:2020-04-20
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