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Systematic approach of chromone skeleton for detecting Mg2+, ion: Applications for sustainable cytotoxicity and cell imaging possibilities.
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy ( IF 4.4 ) Pub Date : 2020-03-21 , DOI: 10.1016/j.saa.2020.118290
Neetu Yadav 1 , Raj Kumar 2 , Ashok Kumar Singh 1 , Shanid Mohiyuddin 3 , P Gopinath 3
Affiliation  

The systematic studies of chromone appended novel chemosensors, favored to Mg2+ ion detection, these were analyzed and characterized by different spectroscopic techniques such as NMR, mass spectroscopy, FTIR and optical techniques. The binding demeanor of the ligands was executed with the library of metal ions and shown the good coordination with Mg2+ ion to the ligand's cavity. Both ligands demonstrated good binding behavior with Mg2+ ion. The ligands represented 1: 1 stoichiometry with Mg2+ ions through Job's plot. The low limit of detection of Mg2+ ion was determined as 2.56 × 10-6 and 1.28 × 10-6 for La and Lb respectively. No interference was occurred in Inference study by foreign metal ions that supported the specific detection of Mg2+ ion among the other metal ions. Further, the cytotoxicity assay test of these chromone appended ligands revealed that both ligands and their respective compound with Mg2+ ion shown negligible toxicity with HeLa cancer cell line. Further, due to the fluorescence properties of the ligands, with or without Mg2+ ion was successfully tested in bioimaging experiment of HeLa cancer cell lines and found that ligands with Mg2+ ions represented good imaging with HeLa cancer cell.

中文翻译:

色酮骨架检测Mg2 +,离子的系统方法:可持续细胞毒性和细胞成像可能性的应用。

色酮附加的新型化学传感器的系统研究,有利于Mg2 +离子检测,已通过NMR,质谱,FTIR和光学技术等不同的光谱技术对其进行了分析和表征。配体的结合行为是通过金属离子库执行的,显示出与Mg2 +离子在配体腔中的良好配位。两种配体均表现出与Mg2 +离子的良好结合行为。通过乔布氏图,配体与Mg2 +离子的化学计量比为1:1。La和Lb的Mg2 +离子检测下限分别为2.56×10-6和1.28×10-6。在推断研究中,没有其他金属离子支持特定检测Mg2 +离子的外来金属离子发生干扰。进一步,这些色酮附加配体的细胞毒性试验表明,这两个配体及其各自具有Mg2 +离子的化合物对HeLa癌细胞的毒性均可以忽略不计。此外,由于配体的荧光特性,在HeLa癌细胞系的生物成像实验中成功测试了有或没有Mg2 +离子,发现具有Mg2 +离子的配体代表了HeLa癌细胞的良好成像。
更新日期:2020-03-22
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