Curcumin, casein and soy soluble polysaccharide ternary complex nanoparticles were produced in the water phase using alkaline dissolution, acidification and high-pressure homogenization. FTIR spectra showed that hydrogen bonding, hydrophobic and electrostatic interactions led to the formation of the nanoparticles. The nanoparticles had strong curcumin solubilizing power. The curcumin concentrations in the nanoparticle dispersions were 2.5–20 mg/mL, the curcumin loading efficiencies were ~97%, and the highest curcumin loading content was 48.6%. The nanoparticles had z-average hydrodynamic diameters of ~3.6 × 10² nm, and good physical stability and curcumin chemical stability after 30 days of storage at 25 °C. Due to the polysaccharide surfaces, the nanoparticles were dispersible in acidic and neutral solutions as well as re-dispersible in water after lyophilization. About 52.3% of the curcumin was released after 2 h digestion in simulated gastric fluid followed by 2 h digestion in simulated intestinal fluid. After oral administration in mice, the nanoparticle treatment group increased the curcumin oral bioavailability by 3.4-fold compared with the curcumin/Tween 20 group. This study showed that the ternary complex nanoparticles were an effective system for curcumin loading, protection and oral delivery.

使用碱性溶解，酸化和高压均质作用，在水相中制备姜黄素，酪蛋白和大豆可溶性多糖三元复合物纳米颗粒。FTIR光谱表明，氢键，疏水和静电相互作用导致纳米颗粒的形成。纳米颗粒具有强的姜黄素增溶能力。纳米颗粒分散液中的姜黄素浓度为2.5–20 mg / mL，姜黄素的负载效率为〜97％，最高的姜黄素负载量为48.6％。纳米粒子的z平均流体动力学直径为〜3.6×10 ² 在25°C下储存30天后，具有良好的物理稳定性和姜黄素化学稳定性。由于多糖的表面，纳米颗粒可分散在酸性和中性溶液中，并且在冻干后可再分散在水中。在模拟胃液中消化2小时后，在模拟肠液中消化2小时后，释放约52.3％的姜黄素。在小鼠中口服给药后，与姜黄素/吐温20组相比，纳米颗粒治疗组将姜黄素的口服生物利用度提高了3.4倍。这项研究表明，三元复合纳米颗粒是姜黄素负载，保护和口服递送的有效系统。