Maghemite (Fe₂O₃-NPs) nanoparticles were synthesized by a convenient, green and cost effective method using aqueous fruit extracts of Hyphaene thebaica. Different techniques like FTIR, XRD, UV–Vis, Raman, HR-TEM, EDS. SAED, Zeta potential were used to establish the nature of Fe₂O₃-NPs, while the therapeutic properties were studied using different biological assays including antiviral, antibacterial, antifungal, antioxidant and enzyme inhibition assays. XRD pattern revealed sharp peaks and a crystalline nature of Fe₂O₃-NPs. HR-TEM revealed quasi-spherical and cuboidal morphologies, while the particle size in ~10 nm. FTIR indicated a sharp peak centered at ~444 cm⁻¹ which is the characteristic FeO band vibration. SAED pattern indicated the crystalline nature while EDS also confirmed the synthesis of Fe₂O₃ NPs. Zeta potential was obtained in different solvents and physiological buffers indicating highest value in water (−26.5 mV) and lowest in DMSO (−15.8 mV). Tested bacterial strains, Bacillus subtilis was found to be inhibited significantly. Aspergillus flavus appeared to be susceptible to all of the tested concentration of Fe₂O₃ NPs. Maximum 40.78% FRSA was obtained at 400 μg/mL. Cell culture based studies on RD cells and L20B cells indicated reduction in viability of cells with increase concentration of Fe₂O₃ NPs. Moderate inhibition of polio virus-1 and polio virus-2 was observed, after culturing the virus in the L20B cells. Excellent Protein Kinase (PK) inhibition was revealed. Hemolytic potential and cytotoxic potential was indicated to be dose dependent. In conclusion, the present report for the first time reports the synthesis of Fe₂O₃ NPs from H. thebaica fruits and reveals their biomedical potential including antiviral potential.

磁石（Fe ₂ O ₃ -NPs）纳米粒子是通过方便，绿色和经济有效的方法，使用Hyphaene thebaica的水性果实提取物合成的。诸如FTIR，XRD，UV-Vis，Raman，HR-TEM，EDS等不同技术。使用SAED，Zeta电位确定Fe ₂ O ₃ -NP的性质，同时使用不同的生物学方法（包括抗病毒，抗菌，抗真菌，抗氧化剂和酶抑制方法）研究治疗性质。XRD图谱显示出尖锐的峰和Fe ₂ O ₃的晶体性质-NP。HR-TEM显示出准球形和长方体形貌，而粒径约为10 nm。FTIR显示出以〜444cm ^-1为中心的尖峰，这是Fe O带振动的特征。SAED图表明其晶体性质，而EDS也证实了Fe ₂ O ₃ NP的合成。在不同的溶剂和生理缓冲液中获得了Zeta电位，表明在水中的最大值（-26.5 mV）在DMSO中的最小值（-15.8 mV）。经测试的细菌菌株枯草芽孢杆菌被发现被显着抑制。黄曲霉菌似乎对所有测试浓度的Fe ₂ O ₃敏感NP。在400μg/ mL下获得最大40.78％FRSA。基于对RD细胞和L20B细胞的细胞培养研究表明，随着Fe ₂ O ₃ NPs浓度的增加，细胞活力降低。在L20B细胞中培养脊髓灰质炎病毒后，观察到对脊髓灰质炎病毒1和脊髓灰质炎病毒2的适度抑制。揭示了极好的蛋白激酶（PK）抑制作用。溶血潜力和细胞毒性潜力表明是剂量依赖性的。综上所述，本报告首次报道了从嗜水杆菌果实中合成Fe ₂ O ₃ NP并揭示了其生物医学潜力，包括抗病毒潜力。