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Non-coding RNAs: Key regulators of aerobic glycolysis in breast cancer.
Life Sciences ( IF 6.1 ) Pub Date : 2020-03-21 , DOI: 10.1016/j.lfs.2020.117579
Min Xia 1 , Shujun Feng 2 , Zuyao Chen 3 , Gebo Wen 1 , Xuyu Zu 4 , Jing Zhong 4
Affiliation  

Although extensive research progress has been made in breast cancer in recent years, yet the morbidity and mortality rates of breast cancer are rising, making it the major disease that endangers women's health. Energy metabolism reprogramming is featured by a state termed "aerobic glycolysis" or the Warburg effect that glycolysis is preferred even under aerobic conditions in neoplastic diseases. Widely acknowledged as an emerging hallmark in cancers, this metabolic switch shows a sophisticated role in the pathogenesis of breast cancer. The regulating effect of non-coding RNAs (ncRNAs) composed of microRNAs, long non-coding RNAs and circular RNAs is closely related to the glycolysis in breast cancer. Therefore, understand the mechanisms of ncRNAs of aerobic glycolysis in breast cancer may provide new strategy for the disease.

中文翻译:

非编码RNA:乳腺癌有氧糖酵解的关键调控因子。

尽管近年来在乳腺癌方面已经取得了广泛的研究进展,但是乳腺癌的发病率和死亡率正在上升,使其成为危害妇女健康的主要疾病。能量代谢重编程的特征是被称为“有氧糖酵解”的状态或沃伯格效应,即即使在赘生性疾病的有氧条件下,糖酵解也是优选的。这种新陈代谢的转换被广泛认为是癌症的新兴特征,在乳腺癌的发病机理中显示出复杂的作用。由microRNA,长非编码RNA和环状RNA组成的非编码RNA(ncRNA)的调节作用与乳腺癌中的糖酵解密切相关。因此,了解乳腺癌好氧糖酵解基因ncRNA的机制可能为该疾病提供新的治疗策略。
更新日期:2020-03-22
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