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Investigating musculoskeletal health and wellbeing; a cohort study protocol
BMC Musculoskeletal Disorders ( IF 2.3 ) Pub Date : 2020-03-21 , DOI: 10.1186/s12891-020-03195-4 Bonnie Millar , Daniel F. McWilliams , Abhishek Abhishek , Kehinde Akin-Akinyosoye , Dorothee P. Auer , Victoria Chapman , Michael Doherty , Eamonn Ferguson , John R. F. Gladman , Paul Greenhaff , Joanne Stocks , Ana M. Valdes , David A. Walsh
BMC Musculoskeletal Disorders ( IF 2.3 ) Pub Date : 2020-03-21 , DOI: 10.1186/s12891-020-03195-4 Bonnie Millar , Daniel F. McWilliams , Abhishek Abhishek , Kehinde Akin-Akinyosoye , Dorothee P. Auer , Victoria Chapman , Michael Doherty , Eamonn Ferguson , John R. F. Gladman , Paul Greenhaff , Joanne Stocks , Ana M. Valdes , David A. Walsh
In an ageing population, pain, frailty and disability frequently coexist across a wide range of musculoskeletal diagnoses, but their associations remain incompletely understood. The Investigating Musculoskeletal Health and Wellbeing (IMH&W) study aims to measure and characterise the development and progression of pain, frailty and disability, and to identify discrete subgroups and their associations. The survey will form a longitudinal context for nested research, permitting targeted recruitment of participants for qualitative, observational and interventional studies; helping to understand recruitment bias in clinical studies; and providing a source cohort for cohort randomised controlled trials. IMH&W will comprise a prospective cohort of 10,000 adults recruited through primary and secondary care, and through non-clinical settings. Data collection will be at baseline, and then through annual follow-ups for 4 years. Questionnaires will address demographic characteristics, pain severity (0–10 Numerical Rating Scale), pain distribution (reported on a body Manikin), pain quality (McGill Pain Questionnaire), central aspects of pain (CAP-Knee), frailty and disability (based on Fried criteria and the FRAIL questionnaire), and fracture risk. Baseline characteristics, progression and associations of frailty, pain and disability will be determined. Discrete subgroups and trajectories will be sought by latent class analysis. Recruitment bias will be explored by comparing participants in nested studies with the eligible IMH&W population. IMH&W will elucidate associations and progression of pain, frailty and disability. It will enable identification of people at risk of poor musculoskeletal health and wellbeing outcomes who might be suitable for specific interventions, and facilitate generalisation and comparison of research outcomes between target populations. The study will benefit from a large sample size and will recruit from diverse regions across the UK. Purposive recruitment will enrich the cohort with people with MSK problems with high representation of elderly and unwell people. Clinicaltrials.gov NCT03696134. Date of Registration: 04 October 2018.
中文翻译:
调查骨骼肌肉的健康状况;队列研究方案
在老龄化的人群中,疼痛,虚弱和残疾经常在各种肌肉骨骼诊断中并存,但对它们之间的联系仍不完全了解。研究性骨骼肌肉健康与福祉(IMH&W)的研究旨在衡量和表征疼痛,虚弱和残疾的发展和进程,并确定离散的亚组及其关联。该调查将构成嵌套研究的纵向环境,允许有针对性地招募参与者进行定性,观察和干预研究;帮助了解临床研究中的招聘偏见;并为队列随机对照试验提供源队列。IMH&W将由通过初级和二级医疗以及非临床环境招募的10,000名成年人组成的预期队列。数据收集将在基线进行,然后通过4年的年度跟踪。问卷将处理人口统计学特征,疼痛严重程度(0-10数字评分表),疼痛分布(在人体模型上报告),疼痛质量(麦吉尔疼痛问卷),疼痛的主要方面(CAP-膝盖),脆弱和残障(基于油炸标准和FRAIL调查表)以及骨折风险。将确定基线特征,进展,虚弱,疼痛和残疾的关联。离散的亚组和轨迹将通过潜在类分析来寻找。通过将嵌套研究的参与者与合格的IMH&W人群进行比较,可以探索招聘偏见。IMH&W将阐明疼痛,虚弱和残疾的关联和进展。它将有助于识别可能适用于特定干预措施的处于风险中的骨骼肌健康状况和健康状况不佳的人,并促进目标人群之间研究结果的概括和比较。这项研究将从大量样本中受益,并将从英国不同地区招募。有目的的招聘将使MSK问题人群中老年人和身体不适者的代表比例更高。Clinicaltrials.gov NCT03696134。注册日期:2018年10月4日。有目的的招聘将使MSK问题人群中老年人和身体不适者的代表比例更高。Clinicaltrials.gov NCT03696134。注册日期:2018年10月4日。有目的的招聘将使MSK问题人群中老年人和身体不适者的代表比例更高。Clinicaltrials.gov NCT03696134。注册日期:2018年10月4日。
更新日期:2020-03-22
中文翻译:
调查骨骼肌肉的健康状况;队列研究方案
在老龄化的人群中,疼痛,虚弱和残疾经常在各种肌肉骨骼诊断中并存,但对它们之间的联系仍不完全了解。研究性骨骼肌肉健康与福祉(IMH&W)的研究旨在衡量和表征疼痛,虚弱和残疾的发展和进程,并确定离散的亚组及其关联。该调查将构成嵌套研究的纵向环境,允许有针对性地招募参与者进行定性,观察和干预研究;帮助了解临床研究中的招聘偏见;并为队列随机对照试验提供源队列。IMH&W将由通过初级和二级医疗以及非临床环境招募的10,000名成年人组成的预期队列。数据收集将在基线进行,然后通过4年的年度跟踪。问卷将处理人口统计学特征,疼痛严重程度(0-10数字评分表),疼痛分布(在人体模型上报告),疼痛质量(麦吉尔疼痛问卷),疼痛的主要方面(CAP-膝盖),脆弱和残障(基于油炸标准和FRAIL调查表)以及骨折风险。将确定基线特征,进展,虚弱,疼痛和残疾的关联。离散的亚组和轨迹将通过潜在类分析来寻找。通过将嵌套研究的参与者与合格的IMH&W人群进行比较,可以探索招聘偏见。IMH&W将阐明疼痛,虚弱和残疾的关联和进展。它将有助于识别可能适用于特定干预措施的处于风险中的骨骼肌健康状况和健康状况不佳的人,并促进目标人群之间研究结果的概括和比较。这项研究将从大量样本中受益,并将从英国不同地区招募。有目的的招聘将使MSK问题人群中老年人和身体不适者的代表比例更高。Clinicaltrials.gov NCT03696134。注册日期:2018年10月4日。有目的的招聘将使MSK问题人群中老年人和身体不适者的代表比例更高。Clinicaltrials.gov NCT03696134。注册日期:2018年10月4日。有目的的招聘将使MSK问题人群中老年人和身体不适者的代表比例更高。Clinicaltrials.gov NCT03696134。注册日期:2018年10月4日。