Smart DNA nanostructures have found potential application in material science and biomedicine. Most building blocks are DNA amphiphiles covalently synthesized from DNA and hydrophobic molecules. Here, the noncovalent approach based on the host-guest interaction between cucurbit[7]uril (CB[7]) and two hydrophobic guests with different topologies is utilized to modularly construct supramolecular DNA amphiphiles including DNA-CB[7]/ferrocene derivative and DNA-CB[7]/adamantine derivative. Both of the supramolecular DNA amphiphiles assemble into uniform spherical micelles, which can encapsulate hydrophobic Nile Red molecules and anchor gold nanoparticles through DNA hybridization. In addition, 1-adamantanamine hydrochloride, a competitive guest with a strong binding constant with CB[7], induces the dissociation of DNA-CB[7]/ferrocene derivative micelles. More importantly, the redox properties of ferrocene induce reversible morphology changes between the spherical micelles and the dissociated state. These stimuli-responsive DNA supra-amphiphilic micelles, as novel vehicles, expand the family of smart DNA nanostructures.

中文翻译：

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超分子DNA两亲物通过宿主-客体相互作用及其刺激反应的自组装。

智能DNA纳米结构已在材料科学和生物医学中发现了潜在的应用。大多数构件是从DNA和疏水分子共价合成的DNA两亲物。在这里，基于葫芦[7]尿素（CB [7]）和两个具有不同拓扑结构的疏水性客体之间的来宾-客体相互作用的非共价方法被用于模块化构建超分子DNA两亲物，包括DNA-CB [7] /二茂铁衍生物和DNA-CB [7] /金刚烷衍生物。两种超分子DNA两亲物均组装成均匀的球形胶束，可包裹疏水的尼罗红分子并通过DNA杂交锚定金纳米颗粒。另外，1-金刚烷胺盐酸盐是一种具有竞争优势的客体，与CB的结合常数强[7]，诱导DNA-CB [7] /二茂铁衍生物胶束的解离。更重要的是，二茂铁的氧化还原性质引起球形胶束和离解态之间可逆的形态变化。这些刺激响应的DNA超两亲胶束，作为新型载体，扩展了智能DNA纳米结构家族。