Observational studies have shown alcohol drinking behaviors may be associated with the risk of amyotrophic lateral sclerosis (ALS), but contradictory findings have emerged, and whether such an association is causal is unclear. We here investigate the causal relationship between alcohol consumption and ALS. By leveraging instruments from large‐scale genome‐wide association studies, we performed a comprehensive Mendelian randomization analysis and found alcohol consumption was causally associated with ALS, leading to ∼1.5‐fold (95% confidence interval = 1.4–3.4) higher risk of ALS for each ∼10g/day increase in alcohol intake. Our findings suggest accumulative alcohol consumption may serve as a crucial risk factor in the pathogenesis of ALS. ANN NEUROL 2020 ANN NEUROL 2020;88:195–198

中文翻译：

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饮酒和 ALS：工具变量因果推断

观察性研究表明，饮酒行为可能与肌萎缩侧索硬化 (ALS) 的风险有关，但出现了相互矛盾的发现，这种关联是否是因果关系尚不清楚。我们在这里调查饮酒和 ALS 之间的因果关系。通过利用大规模全基因组关联研究的仪器，我们进行了全面的孟德尔随机分析，发现饮酒与 ALS 有因果关系，导致 ALS 风险增加约 1.5 倍（95% 置信区间 = 1.4-3.4）酒精摄入量每增加 10 克/天。我们的研究结果表明，累积饮酒可能是 ALS 发病机制中的一个关键风险因素。ANN NEUROL 2020 ANN NEUROL 2020;88:195–198