Trifluoromethylation of alkyl radicals is emerging as a powerful tool for C(sp³)–CF₃ bond formations. Based on the hypothesis of CF₃ group transfer from Cu(II)–CF₃ to alkyl radicals, a number of trifluoromethylation reactions have been developed, including trifluoromethylation of alkyl halides, decarboxylative trifluoromethylation of aliphatic carboxylic acids, C(sp³)–H trifluoromethylation, amino‐ and carbo‐trifluoromethylation of alkenes, etc . Challenges in this intriguing field are also discussed.

中文翻译：

---

烷基自由基的三氟甲基化：突破和挑战†

烷基自由基的三氟甲基化正在成为形成C（sp ³）–CF ₃键的有力工具。基于CF ₃基团从Cu（II）–CF ₃转移至烷基的假设，开发了许多三氟甲基化反应，包括卤代烷的三氟甲基化，脂肪族羧酸的脱羧三氟甲基化，C（sp ³）–H三氟甲基化，烯烃的氨基和碳三氟甲基化等。还讨论了这个有趣领域中的挑战。