The present study aims to: (a) design the versatile microemulsions (MEs) system for drug delivery; (b) use the bovine serum albumin nanoparticles for MEs system development; (c) characterize the physicochemical properties, cytotoxicity, and biocompatibility of the modified MEs (MMEs) system; (d) load of paclitaxel (PTX) and folate conjugate of MEs system; and (e) assess the potential of anticancer activity of MEs system. The physicochemical possessions, in vitro and in vivo cytotoxicity, and stability of MMEs system were characterized. The results of our study show that the MEs system was stable, having narrow particle size distribution, nontoxic, biocompatible, and not active for leukocyte proliferation. So it can be concluded that the MMEs system as a promising candidate for a targeted multifunctional drug delivery system (PTX and folate) that is called a smart MEs system.

中文翻译：

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微乳液和牛血清白蛋白纳米颗粒作为一种新型混合纳米载体系统，用于高效的多功能药物递送。

本研究旨在：（a）设计用于药物递送的多功能微乳液（ME）系统；(b) 使用牛血清白蛋白纳米粒子进行 MEs 系统开发；(c) 表征改性 ME (MME) 系统的理化特性、细胞毒性和生物相容性；(d) MEs系统的紫杉醇(PTX)和叶酸缀合物的负载量；(e) 评估 MEs 系统抗癌活性的潜力。表征了MMEs系统的理化性质、体内外细胞毒性和稳定性。我们的研究结果表明，MEs 系统稳定，粒径分布窄，无毒，生物相容，对白细胞增殖无活性。