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Catalytic Asymmetric Synthesis of Isochroman Derivatives
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2020-03-20 , DOI: 10.1002/adsc.202000243
Tamanna 1 , Mukesh Kumar 2 , Kavita Joshi 1 , Pankaj Chauhan 1
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The isochroman scaffold constitutes an important structural unit, which is present in various bioactive natural products and synthetic pharmaceutical compounds exhibiting wide arrays of biological properties. Hence the synthesis of this class of heterocyclic compounds in a stereoselective fashion is highly significant and desirable. In the last decade, a substantial advancement has been witnessed ln the catalytic asymmetric synthesis of isochroman derivatives by employing metal catalysts bearing chiral ligands or by chiral metal‐free organocatalysts. This review aims to provide an overview of the transition metal‐catalyzed and organocatalyzed asymmetric syntheses of isochroman derivatives including isochromenes and isochromanones.

中文翻译:

异色满衍生物的催化不对称合成

异色满支架构成重要的结构单元,存在于各种生物活性天然产物和具有广泛生物学特性的合成药物化合物中。因此,以立体选择性的方式合成这类杂环化合物是非常重要和合乎需要的。在过去的十年中,通过使用带有手性配体的金属催化剂或无手性金属的有机催化剂,在异色满衍生物的催化不对称合成中取得了显着进步。这篇综述旨在概述过渡金属催化和有机催化的异色满衍生物(包括异色酮和异色满酮)的不对称合成。
更新日期:2020-03-20
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