Tetrasubstituted Furan Fatty acids (FuFAs) are a vital and ubiquitous class of natural products, that upon ingestion afford significant health benefits. Herein, a general and modular approach to their total synthesis is presented, delivering short yet efficient syntheses of two key FuFAs, 11D3 (F₄) and 11D5 (F₆), in 52 % and 48 % overall yield, respectively. Significantly, this method offers an effective route to key analogues, such as decarboxy‐11D3 and decarboxy‐11D5.

中文翻译：

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合成四取代呋喃脂肪酸（FuFAs）的通用收敛策略

四取代的呋喃脂肪酸（FuFAs）是一类至关重要的天然产品，摄入后可带来明显的健康益处。在这里，提出了一种通用的模块化方法进行总合成，以短而有效的方式合成了两种关键的FuFA 11D3（F ₄）和11D5（F ₆），总产率分别为52％和48％。重要的是，该方法为关键的类似物（如脱羧基-11D3和脱羧基-11D5）提供了有效途径。