Techniques for analyzing circulating tumor DNA (ctDNA) to detect, characterize and monitor cancer have matured rapidly. An increasing body of clinical evidence is demonstrating the capabilities of this technology as a diagnostic test. The full potential of ctDNA liquid biopsy in the diagnosis, characterization and management of solid and hematological malignancies will be uncovered through interventional clinical trials evaluating clinical utility. In this Review, we discuss the current landscape of ctDNA liquid-biopsy applications across the cancer continuum and highlight opportunities for clinical investigation.

中文翻译：

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肿瘤学中的循环肿瘤 DNA 和液体活检

分析循环肿瘤 DNA (ctDNA) 以检测、表征和监测癌症的技术已经迅速成熟。越来越多的临床证据证明了这项技术作为诊断测试的能力。ctDNA 液体活检在实体和血液恶性肿瘤的诊断、表征和管理中的全部潜力将通过评估临床效用的介入临床试验来揭示。在这篇综述中，我们讨论了 ctDNA 液体活检在整个癌症连续体中的应用现状，并强调了临床研究的机会。